Two sample MR report
HLA-DQB1_Interstitial Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.0008680 | 0.3011794 | 0.9978120 |
| Weighted median | 7 | -0.0577722 | 0.0326352 | 0.0766866 |
| Inverse variance weighted | 7 | -0.0591257 | 0.0265284 | 0.0258293 |
| Simple mode | 7 | -0.0556670 | 0.0435855 | 0.2487300 |
| Weighted mode | 7 | -0.0552369 | 0.0443258 | 0.2591550 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0050770 | 5 | 0.9999999 |
| Inverse variance weighted | 0.0427854 | 6 | 0.9999984 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0304032 | 0.156567 | 0.8536728 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002222 | 0 | TRUE | 0.156061 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
